| 摘要 |
To provide novel compounds, pharmaceuticals containing the same, especially anti-HIV agents having anti viral activity, especially inhibitory activity against HIV integrase. A compound of the formula:
(wherein:
X represents either one of the following groups:
(wherein, C ring is nitrogen-containing aromatic heterocyclic ring in which at least one atom in atoms neighboring the atom bound to the pyrimidine ring is unsubstituted nitrogen atom;
R 10 is hydrogen or lower alkyl; D ring is aryl or heteroaryl) Z 1 and Z 3 each is independently a single bond, O, S, S (=O) or SO 2 ;
Z 2 is a single bond, lower alkylene or lower alkenylene;
Ar is optionally substituted aryl or optionally substituted heteroaryl;
R 1 is lower alkyl, substituted lower alkyl or the like;
R 2 is a hydrogen atom or optionally substituted lower alkyl;
or R 1 and R 2 may form, together with an adjacent atom, an optionally substituted heterocyclic ring, a pharmaceutically acceptable salt or a solvate thereof.
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