SCREENING METHOD

摘要

This invention arises from the discovery that compounds capable of blocking cellular monocarboxylate transport can inhibit lymphocyte proliferation, offering up these compounds as therapeutic agents in various immune-mediated disorders and cancers. Accordingly, this invention relates, inter alia, to methods of screening compounds for their ability to treat certain cancers and immune-mediated disorders, particularly transplant rejection and rheumatoid arthritis. The invention also relates to methods of treating these diseases by administering a compound or compounds capable of inhibiting monocarboxylate transport and the use of monocarboxylate transport inhibitor compounds in treating such diseases.