FERMENTATIVE PRODUCTION OF D-p-HYDROXYPHENYLGLYCINE AND D-PHENYLGLYCINE
摘要
A new fermentative process for the preparation of D-p-hydroxyphenylglycine (D-HPG) or D-henylglycine (D-pG) in enantiomerically pure form is disclosed. Precursors for the formation of D-HPG and D-pG are withdrawn form the common aromatic amino acid pathway, converted to p-hydroxyphenylglyoxylate or phenylglyoxylate, and are finally converted to D-HPG or D-pG by the action of a stero-inverting D-aminotransferase.
申请公布号
EP1328643(B1)
申请公布日期
2006.09.06
申请号
EP20010982940
申请日期
2001.10.22
申请人
DSM IP ASSETS B.V.;DSM BIOTECH GMBH;JOHNS HOPKINS UNIVERSITY
发明人
TOWNSEND, CRAIG, A.;GUNSIOR, MICHELE;MUELLER, ULRIKE;ASSEMA VAN, FRISO, BERNARD, JAN;SONKE, THEODORUS