| 摘要 |
A dry powder medicament preparation is disclosed. Also methods of forming and loading metered doses of the preparation into dose containers intended for insertion into a dry powder inhaler are disclosed. The preparation is adapted for a dose forming process, which may be based on volumetric filling or electro-dynamic deposition of the powder particles, such that a metered dose of the preparation is characterized by having at least one load of held-together particles joined in a macrostructure of predefined dimensions and presenting an intended mechanical strength. The pharmacologically active ingredient presents at least 50% by mass of particles in a typical aerodynamic diameter range from 1 to 5 mum. Furthermore, a dose thus formed is then loaded into a high barrier container. |
