发明名称 |
Farnesyl transferase inhibitors |
摘要 |
This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.
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申请公布号 |
US7101897(B2) |
申请公布日期 |
2006.09.05 |
申请号 |
US20020110690 |
申请日期 |
2002.04.17 |
申请人 |
ASTRAZENECA AB |
发明人 |
WARDLEWORTH JAMES MICHAEL;BOYLE FRANCIS THOMAS;MATUSIAK ZBIGNIEW |
分类号 |
A61K31/40;A61K31/4439;A61K31/454;A61P35/00;A61P35/02;A61P43/00;C07C229/60;C07D207/12;C07D261/02;C07D401/12 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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