Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme

摘要

The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, R¹, R², R³, R⁴, Z, U, X, Y, Z^a, and n are defined are as defined herein, which are useful as inhibitors of matrix metalloproteinases (MMP) and/or TNF-alpha converting enzyme (TACE), or a combination thereof.