发明名称 |
ANTAGONIST ANTI -CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE |
摘要 |
Methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
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申请公布号 |
IL175225(D0) |
申请公布日期 |
2006.09.05 |
申请号 |
IL20060175225 |
申请日期 |
2006.04.26 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
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分类号 |
A61K38/20;A61K39/395;C07K;C07K16/28 |
主分类号 |
A61K38/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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