5-pyridyl-1,3-azole compounds, process for producing the same and use thereof

摘要

An optionally N-oxidized compound represented by the formula: wherein R¹ represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R² represents an aromatic group, R³ represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR⁴ (R⁴ represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A₃ receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A₃ receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-alpha inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-alpha.