BIOADHESIVE PROGRESSIVE HYDRATION TABLETS AND METHODS OF MAKING AND USING THE SAME

摘要

A BIOADHESIVE TABLET WHEREIN THE ACTIVE ANGREDIENT MAY BE PROTECTED FROM WATER OR THE SURROUNDING ENVIRONMENT, THEREBY PROTECTING IT FROM METABOLISM OR FROM OTHER DEGRADATION CAUSED BY MOISTURE, ENZYMES, OR PH EFFECTS, AND MAKING IT BIOVAILABLE ONLY AT A CONTROLLED RATE. THE ACTIVE INGREDIENT MAY BE PROTECTED FROM MOISTURE DURING THE MANUFACTURING PROCESS AND MORE IMPORTANTLY MAY BE PROTECTED FROM MOISTURE AND THE IMMEDIATE SEPTIC ENVIRONMENT UNTIL AFTER THE PATIENT HAS APPLIED THE TABLET, AND THE ONLY AT A SLOW AND CONTROLLED RATE. IT IS BY THIS PROCESS OF PROGRESSIVE HYDRATION THAT THE ACTIVE INGERDIENT REMAINS PROTECTED FOR MANY HOURS AFTER ADMINISTRATION. IT IS ALSO BY THE PROCESS OF PROGRESSIVE HYDRATION THAT CONTROLLED AND SUSTAINED RELEASE IS ACHIEVED BECAUSE ONLY THAT PART OF THE ACTIVE INGREDIENT THAT IS THE HYDRATED (AQUEOUS) FRACTION OF THE TABLET IS AVAILABLE FOR ABSORPTION (BIOAVAILABLE).FIG 2