<p>The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.</p>
申请公布号
EP1694363(A2)
申请公布日期
2006.08.30
申请号
EP20040814802
申请日期
2004.12.16
申请人
NEKTAR THERAPEUTICS AL, CORPORATION
发明人
BENTLEY, MICHAEL, D.;VIEGAS, TACEY, X.;GOODIN, RICHARD, R.;CHENG, LIN;ZHAO, XUAN