1-N-phenylamino-1H-imidazole derivatives as aormatase inhibitors

摘要

A method and composition for the prevention, amelioration or control of external parasites on animals and humans utilizing a compound of formula I. wherein R is halogen, OR7, SOmR8, NO2, CN, C1-C6haloalkyl or an optionally substituted C1-C6alkyl group; n is 0 or an integer of 1, 2 or 3; m is 0 or an integer of 1 or 2; R1  is H, halogen, NO2, NR9R10, NR11COR12, NCHNR9R10 or NCHOR13; R2, R3, R4, R5 and R6   are each independently H, halogen or a C1-C4alkyl, aryl or heteroaryl group each optionally substituted; R7  is H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl or heteroaryl group each optionally substituted; R8  is a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl or heteroaryl group, each optionally substituted; R9 and R10   are each independently H, C1-C4haloalkyl or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl or heteroaryl group each optionally substituted or R9 and R10 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing 1 or 2 additional heteroatoms selected from O, N or S; R11   is H, COR12 or an optionally substituted C1-C4alkyl group; R12   is a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl or heteroaryl group each optionally substituted; and R13   is H or a C1-C6alkyl, aryl or heteroaryl group each optionally substituted; or a stereoisomer or tautomer thereof.