| 摘要 |
<p>The invention relates to a modified release pharmaceutical composition and to the use thereof. The modified release pharmaceutical composition comprising amoxicillin and sodium clavulanate in a ratio of 14:1 ... 20:1, contains the entire amount of potassium clavulanate and a first amount of amoxicillin together with pharmaceutically acceptable excipients allowing the quick release of potassium clavulanate, in order to form a quick release phase, and also comprises a second amount of amoxicillin formulated together with pharmaceutically acceptable excipients, allowing a retard release of a second amount of amoxicillin, forming a retard release phase, wherein the amoxicillin ratio is of 3:1 ... 1:3 in the retard and in the quick release phases. according to the invention, the pharmaceutical composition is used for producing a medicine for treating bacterial infections in humans, determined by S pneumoniae organisms, including drug resistant and penicillin resistant S-pneumoniae , H influenzae and/or M catarrhalis.</p> |
