| 摘要 |
<p>Compound (I) is reacted with compound (II) to give compound (III), which is then reacted with compound (IX) to give compound (VIII), which is then preferably deprotected by an enzyme reaction to give compound (XII). The present invention provides an advantageous process for preparing a pyrimidine derivative useful as an enzyme inhibitor, and a synthetic intermediate:
wherein P is an alkyl group and the like, R 1 and R 2 are alkyl groups and the like, R 3 is an alkyl group optionally having substituent(s) and the like, R 4 is a hydrogen atom and the like, R 5 is an aralkyl group optionally having substituent(s) and the like, and Y is a heteroaryl group optionally having substituent(s) and the like.</p> |
