| 摘要 |
The invention relates to a medicament which comprises, in a pharmaceutically-acceptable vehicle, an antipsychotic agent or an antidepressant agent (A), the only adverse effect thereof being weight gain or sedation, and an antagonist and/or inverse agonist (B) of histamine receptor H3, said antagonist and/or inverse agonist of histamine receptor H3 being present in a therapeutically- effective quantity such as to provide at least one of the following three effects: suppression or at least limitation of the adverse weight gain effect, suppression or limitation of the adverse effect on vigilance, epilepsy/convulsions, increase in the pro-cognitive effect of the treatment. The invention also relates to one such antagonist or inverse agonist for the preparation of a medicament that is intended to provide at least one of the aforementioned effects in a patient being treated with one such antipsychotic or antidepressant agent.
|
