Sustained-release tramadol formulations with 24-hour efficacy
摘要
A solid dosage formulation having a core with a pharmacological agent dispersed in a first controlled-release matrix from which release of the agent is relatively slow; and a coat formed over the core and having the agent dispersed in a second controlled-release matrix from which release of the agent is relatively fast. The first matrix can be a cross-linked high amylose starch and the second matrix can be a mixture of polyvinyl acetate and polyvinylpyrrolidone.
申请公布号
ZA200504216(B)
申请公布日期
2006.08.30
申请号
ZA20050004216
申请日期
2005.05.24
申请人
LABOPHARM INC;LABOPHARM EUROPE LIMITED;LABOPHARM (BARBADOS) LIMITED
发明人
VINCENT LENAERTS;OUADI-NJIKI, PATRICIA, L.;JONATHAN BACON;RACHIN OUZEROUROU;SONIA GERVAIS;MILOUD RAHMOUNI;DAMON SMITH