发明名称 |
EFFERVESCENT MIXTURE WITH ALKALI METAL SALTS OR LYSINATES OFACIDIC, INSOLUBLE OR SLIGHTLY SOLUBLE ACTIVE INGREDIENTS |
摘要 |
The effervescent mixture contains at least one acidic, insoluble or slightly soluble pharmaceutical active ingredient in the form of its soluble alkali metal salt or lysinate, which is present as an intimate mixture with the alkaline component and preferably coats the particles of the alkaline component of the effervescent system, for example sodium bicarbonate and/or sodium carbonate. Both components in very finely powdered form may also be present as granules, with the aid of a binder. In particular, the effervescent mixture contains, per 100 parts of active ingredient, at least 0.5 part, preferably 1 to 3 parts, of a surfactant, in particular dioctyl sulfosuccinate, and/or at least 1 part, preferably 3 to 5 parts, of a binder or suspending agent, in particular polyvinylpyrrolidone. The acidic component of the effervescent system is passivated on the surface. |
申请公布号 |
CA2131515(C) |
申请公布日期 |
2006.08.29 |
申请号 |
CA19942131515 |
申请日期 |
1994.09.06 |
申请人 |
GERGELY, GERHARD;GERGELY, THOMAS;GERGELY, IRMGARD;GERGELY, STEFAN |
发明人 |
GERGELY, GERHARD;GERGELY, THOMAS;GERGELY, IRMGARD;GERGELY, STEFAN |
分类号 |
A61K9/46;A23L27/00;A61K45/00 |
主分类号 |
A61K9/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|