[[2-(Amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

摘要

This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R¹ is H, alkyl or phenylalkyl; R² is H, alkyl, alkenyl or phenylalkyl; or R¹ and R² taken together as Z are -CH₂CH₂-, -CH₂(CR⁶)(R⁷)CH₂- or -CH₂C(R⁸)(R⁹)-C(R¹⁰)(R¹¹)CH₂-, where R⁶, R⁸ and R¹⁰ are, independently, H, alkyl or hydroxyl and R⁷, R⁹ and R¹¹ are, independently, H or alkyl; A is alkylene or alkenylene; X is CO₂R³, P(O)(OR⁴)(OR⁵), 3,5-dioxo-1,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R³, R⁴ and R⁵ are, independently, H or alkyl, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula (I).