发明名称 |
Thiophene hydroxamic acid derivatives |
摘要 |
The (R) and (S) enantiomers of a compound of formula I are novel antiproliferative therapeutic agents. These compounds have HDAC inhibitor activity and are useful in the treatment of cancer. Also disclosed are methods of making and using compounds of formula (I), as well as pharmaceutical compositions containing compounds of formula (I).
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申请公布号 |
US7098241(B2) |
申请公布日期 |
2006.08.29 |
申请号 |
US20030732633 |
申请日期 |
2003.12.10 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
GROSSMANN ADELBERT;HERTING FRANK;KOERNER MATTHIAS;KUENKELE KLAUS-PETER;LIMBERG ANJA;MUNDIGL OLAF;TIBES ULRICH |
分类号 |
A61K31/38;A61K31/381;A61K31/4025;A61K31/422;A61K31/4436;A61P35/00;C07D333/22;C07D333/38;C07D409/12;C07D413/12 |
主分类号 |
A61K31/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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