发明名称 |
Method of utilizing neurotrophins to manipulate reproductive capacity |
摘要 |
Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of the oocytes. Administration of antagonists act as a contraceptive because the antagonists prevent the neurotrophins from binding to oocyte receptors. Neurotrophins may also be used to stimulate the maturation of oocyte in vitro.
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申请公布号 |
US7097984(B2) |
申请公布日期 |
2006.08.29 |
申请号 |
US20020209779 |
申请日期 |
2002.07.31 |
申请人 |
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
SEIFER DAVID B;SHELDEN ROBERT;FENG BO;DREYFUS CHERYL |
分类号 |
G01N33/53;A61K31/352;A61K38/18;A61P1/00;G01N33/533;G01N33/534;G01N33/74 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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