发明名称 |
Non-endogenous, constitutively activated known G protein-coupled receptors |
摘要 |
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known ("known GPCRs"), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.
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申请公布号 |
US7097969(B2) |
申请公布日期 |
2006.08.29 |
申请号 |
US20040925095 |
申请日期 |
2004.08.24 |
申请人 |
ARENA PHARMACEUTICALS, INC. |
发明人 |
LEHMANN-BRUINSMA KARIN;LIAW CHEN W.;LIN I-LIN |
分类号 |
C12Q1/00;G01N33/50;A61K38/00;C07K14/705;C07K14/72;C12N15/12;C12Q1/02;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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