| 摘要 |
FIELD: medicine, pharmaceutical technology, pharmacy. ^ SUBSTANCE: invention relates to producing solid combined medicinal formulations of preparations exhibiting an antihypertensive effect, increasing heart blow-out index and enhancing tolerance to physical load in patient with the congestive cardiac insufficiency. The proposed medicinal agent comprises the following components, wt.-%: perindopril erbumine, 0.6-7.0; microcrystalline cellulose, 12.0-35.0; magnesium stearate, 0.3-1.7; aerosil, 0.1-1.0; croscarmelose-sodium, 1.1-7.0, and lactose, the balance. Also, invention discloses a method for preparing the medicinal formulation. Invention reduces loss of perindopril in process for the formulation preparing, retaining the parent properties of perindopril erbumine and enhancing biological availability of agent. ^ EFFECT: enhanced and valuable properties of agent, improved preparing method. ^ 3 cl, 2 tbl, 2 ex |
