发明名称 |
COMBINATION MOTIF IMMUNE STIMULATORY OLIGONUCLEOTIDES WITH IMPROVED ACTIVITY |
摘要 |
A class of immunostimulatory nucleic acids having at least two functionally and structurally defined domains is provided. This class of combination motif immunostimulatory nucleic acids activates an immune response and is useful for treating a variety of immune related disorders such as cancer, infectious disease, and allergic disorders. The nucleic acids also stimulate activation of natural killer cells and production of type 1 interferon. |
申请公布号 |
EA007232(B1) |
申请公布日期 |
2006.08.25 |
申请号 |
EA20040000319 |
申请日期 |
2002.08.19 |
申请人 |
COLEY PHARMACEUTICAL GMBH;UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
KRIEG ARTHUR, M.;VOLLMER JORG;ULHMAN EUGEN |
分类号 |
A61K48/00;C12N15/09;A61K31/7115;A61K38/00;A61P11/06;A61P31/00;A61P35/00;A61P37/04;A61P37/08;C12N5/10;C12N15/00;C12N15/11;C12N15/117;C12N15/88;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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