发明名称 |
SPHINGOSINE 1- PHOS PHATE AGONISTS COMPRISING CYCLOALKANES AND 5 -MEMBERED HETEROCYCLES SUBSTITUTED BY AMINO AND PHENYL GROUPS |
摘要 |
<p>The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P<SUB>1</SUB> receptor type. The compounds invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.</p> |
申请公布号 |
WO2006088944(A1) |
申请公布日期 |
2006.08.24 |
申请号 |
WO2006US05304 |
申请日期 |
2006.02.14 |
申请人 |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION;LYNCH, KEVIN, R.;MACDONALD, TIMOTHY, L. |
发明人 |
LYNCH, KEVIN, R.;MACDONALD, TIMOTHY, L. |
分类号 |
A61K31/137;A61K31/341;A61K31/381;A61K31/40;A61K31/402;A61K31/415;A61K31/42;A61K31/425;A61K31/661;A61K31/662;A61K31/665;A61K31/67;A61K31/675;A61P1/00;A61P7/12 |
主分类号 |
A61K31/137 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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