CATALYST FOR ASYMMETRIC SYNTHESIS, LIGAND FOR USE THEREIN, AND PROCESS FOR PRODUCING OPTICALLY ACTIVE COMPOUND THROUGH ASYMMETRIC SYNTHESIS REACTION USING THEM

摘要

Compounds of the following general formula (1a) or (1b). (1a) (1b) Further, there are provided a complex comprising a central metal of rhodium and any of compounds of the general formula (1a) or (1b) as a ligand; comprised of this complex, a catalyst for optically active ß-substituted carbonyl compound synthesis and catalyst for asymmetric 1,2 addition reaction; using these catalysts, a process for producing an optically active ß-aryl compound from an a,ß-unsaturated compound and an arylboronic acid derivative and process for producing an optically active aryl alcohol compound from an aldehyde compound and an aryl boronic acid derivative; a complex comprising a central metal of palladium and any of compounds of the general formula (1a) or (1b) as a ligand; comprised of this complex, a catalyst for asymmetric allyl-position substitution reaction; and using this catalyst, a process for producing an optically active dialkyl (1,3-disubstituted propenyl)malonate compound from a 1,3-disubstituted allyl acetate compound and a dialkyl malonate and process for producing an optically active allylamine compound from a 1,3-disubstituted allyl acetate compound and an amine compound. The compounds have not only the versatility of being usable in the synthesis of wide-ranging optically active aryl compounds but also the selectivity and reactivity permitting synthesis with high yield within a short period of time under industrially advantageous mild conditions.