Pyridazinone and triazinone compounds and use thereof as pharmaceutical preparations

摘要

The present invention provides a novel compound exhibiting an excellent inhibitory action on AMPA receptor and/or kainate receptor. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, A¹, A² and A³ are independent of each other and each represents a C_3-8 cycloalkyl group, a C_3-8 cycloalkenyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may be substituted; Q represents O, S or NH; Z represents C or N; X¹, X² and X³ are independent of each other and each represents a single bond, an optionally substituted C_1-6 alkylene group, an optionally substituted C_2-6 alkenylene group, an optionally substituted C_2-6 alkynylene group, -NH-, -O-, -NHCO-, -CONH-, -SO_0-2-, etc.; R¹ and R² are independent of each other and each represents a hydrogen atom or an optionally substituted C_1-6 alkyl group, or R¹ and R² may be bound together such that CR²-ZR¹ forms C-C; and R³ represents a hydrogen atom or an optionally substituted C_1-6 alkyl group etc., or may be bound to any atom in A¹ or A³ to form, together with the atom, an optionally substituted C_5-8 hydrocarbon ring or an optionally substituted 5- to 8-membered heterocyclic ring.