This disclosure provides a new class of compounds referred to as "reversed chloroquines" (RCQs), which are highly effective against CQ<SUP>R</SUP> and CQ<SUP>S</SUP> malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQ<SUP>R</SUP> reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQ<SUP>R</SUP> or CQ<SUP>S</SUP> Plasmodium
申请公布号
WO2006088541(A2)
申请公布日期
2006.08.24
申请号
WO2005US44978
申请日期
2005.12.12
申请人
STATE OF OREGON ACTING BY & THROUGH THE STATE BOARD OF HIGHER EDU. ON BEHALF OF PORTLAND STATE UNV.;PEYTON, DAVID, H.;BURGESS, STEVEN