METHOD, SYSTEM AND SOFTWARE FOR CARRYING OUT BIOLOGICAL INTERPRETATIONS OF MICROARRAY EXPERIMENTS

摘要

The invention relates to DNA microarray data analysis. A p-value of each gene of a cluster, such as a pathway given by a database, is calculated on the basis of fluorescence signals issued from a microarray chip, corresponding to a probability that the gene is reported as being differentially expressed between several cell types, under a certain condition. Clusters from pre-existing databases containing a given number of genes of the microarray are formed, and, for each cluster, significant genes are selected with respect to their p-values. According to the invention, genes of the microarray are randomly drawn in order to evaluate a Z-score indicating a significance of each cluster.