Polyamine conjugates with acidic retinoids and preparation thereof

摘要

Invented are novel polyamine conjugates which have been readily obtained using as key-step the condensation of linear, conformationally restricted, cyclic and branched polyamides or suitably protected derivatives with vitamin A derivatives. These compounds inhibit the ribozyme rivbonuclease P (RNase P) and the production of interleukin-2 (IL-2) amd interferon-gamma (INF-gamma) by peripheral blood mononuclear cells in vitro.