MULTIMICROPARTICULATE ORAL PHARMACEUTICAL FORM WITH MODIFIED RELEASE OF ANGIOTENSIN II RECEPTOR ANTAGONISTS

摘要

The invention relates to oral pharmaceutical forms with modified release of ARB, as well as to related treatments and delivery methods. The invention concerns a form with modified release of ARB which prolongs the bioabsorption time and enables the pharmaceutical form to be administered only once daily. Therefore the invention concerns an oral pharmaceutical form with modified ARB release comprising a plurality of ARB units (mean diameter: 50-1000 ?m) leading, after being taken, to a plasmatic profile wherein C18h* = C18h, with C18h = plasmatic ARB concentration, 18h after being taken, C18h*= plasmatic ARB concentration corresponding to C18h and obtained in similar conditions as C18h, with a reference immediate release oral pharmaceutical form, containing a similar ARB dose, Cmax = maximum plasmatic ARB concentration after being taken, Cmax* = maximum plasmatic ARB concentration corresponding to Cmax and obtained in similar conditions as Cmax, with a reference immediate release oral pharmaceutical form*, containing a similar ARB dose.