发明名称 |
Regioselective halogenation of nicotine and substituted nicotines |
摘要 |
A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
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申请公布号 |
US2006189812(A1) |
申请公布日期 |
2006.08.24 |
申请号 |
US20060413281 |
申请日期 |
2006.04.28 |
申请人 |
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发明人 |
COMINS DANIEL L.;FEVRIER FLORENCE;SMITH EMILIE D. |
分类号 |
C07D403/04;A61K31/4439;A61K31/695;C07F1/02;C07F7/08 |
主分类号 |
C07D403/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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