<p>A process for separating enantiomers or isomers present in a liquid phase through formation and then subsequent decomposition of a host-guest complex coupled to membrane nanofiltration, comprising the steps of: (a) providing a first solution comprising at least two enantiomers or isomers A and B of a guest molecule; (b) adding a host molecule to this first solution; (c) forming a host-guest complex, such that the ratio between the enantiomers or isomers A and B in the host-guest complex is enriched in A over B relative to the first solution; (d) substantially separating the host-guest complex from the non-complexed B enantiomer or isomer; (e) decomposing the host-guest complex into the host and guest molecules to form a second solution; (f) providing a selectively permeable membrane having a first surface and a second surface; (g) separating the guest molecule and host molecule by transferring the guest molecule from the first surface to the second surface across the membrane by contacting the second solution with the first surface. In step (g), the pressure at the first surface is greater than the pressure at the second surface, and the membrane is a selectively permeable such that the membrane rejection (R<SUB>host</SUB>) of the host molecule is greater than the rejection (R<SUB>guest</SUB>) of the guest molecule.</p>
