摘要 |
<p>Substituted pyrazole compounds such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.</p> |
申请人 |
MERCK & CO., INC.;PINKERTON, ANTHONY, B.;CUBE, ROWENA;HUTCHINSON, JOHN;HUANG, DEHUA;VERNIER, JEAN-MICHEL;SHEN, DONG-MING |
发明人 |
PINKERTON, ANTHONY, B.;CUBE, ROWENA;HUTCHINSON, JOHN;HUANG, DEHUA;VERNIER, JEAN-MICHEL;SHEN, DONG-MING |