| 摘要 |
The invention features methods of preventing or treating epithelial cell lesions in a mammal by administering a composition containing a therapeutically effective amount of a trefoil domain-containing polypeptide, or a trefoil peptide fragment, and a mucoadhesive excipient. The invention further features methods of preventing or treating an eye disorder, e.g., dry eye, by topically administering to the eye a composition containing a therapeutically effective amount of a trefoil domain-containing polypeptide, or a trefoil peptide fragment, and a mucoadhesive excipient. Compositions containing a trefoil domain-containing polypeptide, or a trefoil peptide fragment, and a mucoadhesive excipient may be formulated in combination with one or more additional therapeutic agents and used in the methods of the invention.
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