发明名称 |
Process of thermodynamical activation of water-insoluble drugs loaded into cross linked polymers |
摘要 |
The present invention refers to a process to prepare a highly activated composite of one or more water-insoluble drugs, said process comprising the steps of: (a) subjecting said water-insoluble drug and a cross-linked polymer to co-grinding; (b) exposing the ground product of step a. to contact with water or water vapors. The resulting composite contains large amounts of drug in the easily soluble amorphous form, reduced amounts of drug in the nanocrystalline form, and is substantially free from practically insoluble drug crystals. |
申请公布号 |
AU2002321061(B2) |
申请公布日期 |
2006.08.24 |
申请号 |
AU20020321061 |
申请日期 |
2002.06.03 |
申请人 |
EURAND PHARMACEUTICALS LTD |
发明人 |
LORENZO MAGAROTTO;LUCA DOBETTI;, MASSIMO BRESCIANI |
分类号 |
A61J3/06;A61K9/16;A61K9/06;A61K9/08;A61K9/10;A61K9/14;A61K9/20;A61K9/48;A61K9/50;A61K47/32;A61K47/36;A61K47/38 |
主分类号 |
A61J3/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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