| 摘要 |
The present invention concerns compounds of formula (I), the N -oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C 5-12 alkanediyl; n is 1 or 2; p is 1 and q is 2; or p is 2 and q is 1; X is -O-, -S-, -S(=O)-, -S(=O) 2 - or NR 2 ; each R 1 is independently hydrogen, halogen, C 1-6 alkyl, nitro, hydroxy or C 1-4 alkyloxy; R 2 is hydrogen, C 1-6 alkyl, aryl or C 1-6 alkyl substituted with aryl; aryl is phenyl or phenyl substituted with a halogen or C 1-6 alkyl; D is an optionally substituted benzophenone or 3- benzisoxazolyl; having central alpha 2 -adrenoceptor antagonist activity. It further relates to their preparation, pharmaceutical use and compositions.
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