发明名称 |
Androgen receptor-dependent gene expression control |
摘要 |
The invention relates to the use of at least one siRNA ("short interfering RNA") and/or at least one anti-LSD1 antibody for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal or for the manufacture of a medicament for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. The invention also relates to a pharmaceutical composition for controlling the androgen receptor-dependent gene expression, comprising an effective dose of at least one siRNA and/or at least one anti-LSD1 antibody suitable for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. The invention also relates to a method for controlling the androgen receptor-dependent gene expression in a mammal, said process comprising the step of administering to said mammal, on a suitable route, an effective dose of a pharmaceutical composition modulating an activity of the lysine-specific demethylase (LSD1) in a mammal. |
申请公布号 |
EP1693062(A2) |
申请公布日期 |
2006.08.23 |
申请号 |
EP20050015253 |
申请日期 |
2005.07.13 |
申请人 |
UNIVERSITAETSKLINIKUM FREIBURG |
发明人 |
SCHUELE, ROLAND, PROF.;METZGER, ERIC, DR. |
分类号 |
A61K31/7088;A61K39/00;A61K48/00;A61P35/00;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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