发明名称 |
Cationic lipid compositions targeting angiogenic endothelial cells |
摘要 |
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
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申请公布号 |
US7094424(B2) |
申请公布日期 |
2006.08.22 |
申请号 |
US20030700735 |
申请日期 |
2003.11.03 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MCDONALD DONALD M.;MCLEAN JOHN;THURSTON O. GAVIN;BALUK PETER |
分类号 |
A61K9/127;G01N33/50;A61K31/7088;A61K45/06;A61K47/48;A61K49/00;A61P35/00;C12N15/88 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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