发明名称 |
Oral farmaceutisk doseringsform omfattende en kombination af en opioid-agonist og naltrexon |
摘要 |
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative "aversive" experience in physically dependent addicts (e.g., precipitated abstinence syndrome). |
申请公布号 |
DK1041987(T3) |
申请公布日期 |
2006.08.21 |
申请号 |
DK19980964853T |
申请日期 |
1998.12.22 |
申请人 |
EURO-CELTIQUE S.A. |
发明人 |
KAIKO, ROBERT, F.;COLUCCI, ROBERT, D. |
分类号 |
A61K31/485;A61K45/06;A61K9/22;A61K31/135;A61K31/439;A61K31/451;A61P25/04;A61P25/20;A61P25/36;A61P43/00 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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