发明名称 |
IN VITRO GENERATION OF GABAERGIC NEURONS FROM EMBRYONIC STEM CELLS AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS |
摘要 |
<p>The present disclosure is directed to improved methods for efficiently producing neuroprogenitor cells and differentiated neural cells such as GABAergic neurons from pluripotent stem cells, for example embryonic stem cells. Using the disclosed methods, cell populations containing a high proportion of GABAergic neurons have been isolated. The neuroprogenitor cells and terminally differentiated cells of the present disclosure can be generated in large quantities, and therefore may serve as an excellent source for cell replacement therapy in neurodegenerative disorders and neuronal diseases such as stroke, ischemia, epilepsy, and Huntington's disease.</p> |
申请公布号 |
KR20060091296(A) |
申请公布日期 |
2006.08.18 |
申请号 |
KR20067004487 |
申请日期 |
2004.09.02 |
申请人 |
RELIANCE LIFE SCIENCES PVT., LTD. |
发明人 |
KHAN FIRDOS ALAM;TOTEY SATISH MAHADEORAO |
分类号 |
C12N5/0793;A61K35/12;A61P25/00;C12N5/0789 |
主分类号 |
C12N5/0793 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|