COMPOSITIONS AND METHODS FOR TREATING STAT-6 ASSOCIATED DISEASES OR CONDITIONS

摘要

The present invention relates to a cell permeable peptide to specifically inhibit tyrosine phosphorylation and/or subsequent activation of STAT-6. This peptide is composed of a protein transduction moiety operably linked to a portion of STAT-6 which contains tyrosine residue 641 (Tyr-641) of STAT-6, wherein Tyr-641 is phosphorylated. The chimeric STAT-6 peptide enters cells and binds to the SH2 domain of wild-type STAT-6, and subsequently inhibits dimerization and nuclear translocation of the wild-type STAT-6 protein. Administration of this chimeric peptide inhibits allergen-induced airway inflammation, cytokine production and airway hyperresponsiveness and is useful in methods for preventing or treating diseases or conditions associated with STAT-6 activation.