发明名称 |
Prevention and treatment of atherosclerosis by reducing carbamylation of LDL or the effects of carbamylated LDL |
摘要 |
The present invention provides a method of determining whether an individual is at risk for atherosclerosis, comprising the step of measuring the level of cLDL and/or autoantibody to cLDL in a sample obtained from this individual. The invention further discloses a method of reducing carbamylation in an individual with a monomeric amino acid or other enzymatic or non-enzymatic inhibitors of carbamylation. The instant invention also provides a method to decrease the level of cLDL by direct elimination of cLDL from the blood or plasma of an individual. The invention also provides a method of treating or preventing atherosclerosis in an individual by inhibiting aggregation and/or deposition of cLDL in the individual.
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申请公布号 |
US2006183245(A1) |
申请公布日期 |
2006.08.17 |
申请号 |
US20060350660 |
申请日期 |
2006.02.09 |
申请人 |
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发明人 |
SHAH SUDHIR V.;BASNAKIAN ALEXEI G.;BARRI YOUSRI M. |
分类号 |
G01N33/543;C07K16/18;G01N33/92 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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