| 摘要 |
Liposomes are known to enhance the activity of K- (B-) type CpGs which trigger the production of IL-12. In the present invention, the surprising finding was made that liposomes also enhance the activity of D- (A-) type CpGs, leading to the production of IFNalpha in vivo. These findings are relevant for the humans situation, since IFNalpha rather than IL-12 is the key cytokine for the induction of Th1 responses and anti-viral protection in humans.
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