发明名称 |
Thiazole-based nitric oxide donors having acyl substuent(s) and uses thereof |
摘要 |
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
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申请公布号 |
US2006183913(A1) |
申请公布日期 |
2006.08.17 |
申请号 |
US20050266443 |
申请日期 |
2005.11.04 |
申请人 |
RENOPHARM LTD. |
发明人 |
ASSAF PETER;GAZALEEN-MARIEE ELHAM;NAVEH MICHAEL |
分类号 |
C07F5/02;A61K31/427;C07D277/04;C07D277/22;C07D277/24;C07D277/34;C07D277/36;C07D277/42;C07D417/04;C07D417/06;C07D417/10;C07D417/12;C07D495/04 |
主分类号 |
C07F5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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