USE OF CONSENSUS SEQUENCE AS VACCINE ANTIGEN TO ENHANCE RECOGNITION OF VIRULENT VIRAL VARIANTS
摘要
The invention provides consensus sequences for hepatitis C virus 1a and 1b. Also provided are non-synonymous changes for each residue of the consensus sequences. These sequences are useful as compositions or vaccines for prophylactic use or treating HCV-infected individuals. Also provided are methods for lessening the chances for a HCV-infected individual to enter a chronic phase of infection and methods of diagnosing an individual with HCV 1a or HCV 1b infection.
申请公布号
WO2006086188(A2)
申请公布日期
2006.08.17
申请号
WO2006US03514
申请日期
2006.01.31
申请人
THE JOHNS HOPKINS UNIVERSITY;RAY, STUART, C.;COX, ANDREA, L.;THOMAS, DAVID, L.