摘要 |
A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents (see structures) wherein the group R<SUP>4</SUP> represents halogen, CF<SUB>3</SUB>, or H, provided that the maximum number of CF<SUB>3</SUB> groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R<SUP>1</SUP>, R<SUP>2</SUP> and R<SUP>3</SUP> and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed. |
申请人 |
BAYER PHARMACEUTICALS CORPORATION;BRENNAN, CATHERINE;DIXON, JULIE, A.;SCOTT, WILLIAM, J.;REDMAN, ANIKO;JONES, BENJAMIN, D.;PHILLIPS, BARTON;WICKENS, PHILIP;ENYEDY, ISTVAN;KUMARASINGHE, ELLALAHEWAGE;KREIMAN, CHARLES;DUMAS, JACQUES;KHIRE, UDAY;CHUANG, CHIH-YUAN;KLUENDER, HAROLD, C. E.;HONG, ZHENQIU;WANG, LEI;BIERER, DONALD |
发明人 |
BRENNAN, CATHERINE;DIXON, JULIE, A.;SCOTT, WILLIAM, J.;REDMAN, ANIKO;JONES, BENJAMIN, D.;PHILLIPS, BARTON;WICKENS, PHILIP;ENYEDY, ISTVAN;KUMARASINGHE, ELLALAHEWAGE;KREIMAN, CHARLES;DUMAS, JACQUES;KHIRE, UDAY;CHUANG, CHIH-YUAN;KLUENDER, HAROLD, C. E.;HONG, ZHENQIU;WANG, LEI;BIERER, DONALD |