| 摘要 |
<p>This application describes fluormated (+)PHNO and analogs thereof, including radiolabeled analogs, of Formula (I), wherein R<SUP>1</SUP> is C<SUB>1-6</SUB> alkyl in which one hydrogen atom on the alkyl chain is replaced with fluoro or radioactive fluoro. The application further describes compositions comprising these compounds and methods of using these compounds The compounds of formula (I), have good affinity and selectivity for the dopamine D2 receptors and are therefore useful for the labelling of dopamine D2 receptors in vivo and for the identification and quantification of the extent of dopamine supersensitivity in the bram in various stages of a dopamine-related disease.</p> |
