METHODS AND APPARATUSES FOR NONINVASIVE DETERMINATIONS OF ANALYTES

摘要

A new family of methods to improve the accuracy of analyte concentrations measured in samples that both absorb and scatter light. A novel family of methods for determining analyte concentrations in a sample from one or more optical measurements. These methods improve the accuracy of analyte determinations in material samples that both scatter and absorb light. These methods can measure new samples with optical properties that are different from the samples used to calibrate the method. This overcomes a known limitation for applying existing methods in many practical applications where the method appears to perform well on a calibration set but performs poorly on new sample types that require extrapolation or interpolation. These new methods also overcome limitations in applying linear prediction methods based on Beer's law to samples that span a range of optical measurement or sample properties that violates its inherent assumptions.