发明名称 |
[1,2,4]-DITHIAZOLI(DI)NE DERIVATIVES, INDUCERS OF GLUTHATHIONE-S-TRANSFERASE AND NADPH QUINONE OXIDO-REDUCTASE, FOR PROPHYLAXIS AND TREATMENT OF ADVERSE CONDITIONS ASSOCIATED WITHCYTOTOXICITY IN GENERAL AND APOPTOSIS IN PARTICULAR |
摘要 |
The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]- dithiazolidine-3,5-diylidene-diamine derivatives as inducers of glutha-thione-S- transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament useful in the for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein the symbols have the meanings given in the specification. |
申请公布号 |
CA2597523(A1) |
申请公布日期 |
2006.08.17 |
申请号 |
CA20062597523 |
申请日期 |
2006.02.08 |
申请人 |
SOLVAY PHARMACEUTICALS B.V. |
发明人 |
VAN VLIET, BERNARD J.;VAN SCHARRENBURG, GUSTAAF J. M.;PRAS-RAVES, MARIA L.;KEIZER, HISKIAS G.;FEENSTRA, ROELOF W. |
分类号 |
C07D285/01;A61K31/425;A61K31/427;A61P25/28;C07D401/12;C07D403/12 |
主分类号 |
C07D285/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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