Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications

摘要

Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X₁-Y-X₂, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X₁ and X₂ are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X₁ and X₂ are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.