| 摘要 |
A method and compound for treating skeletal muscle mass deficiency in a huma n subject are disclosed. The composition is an oligomer of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitroge n of one subunit to a 51 exocyclic carbon of an adjacent subunit, contains between 10-40 nucleotide bases, has a base sequence effective to hybridize t o an expression-sensitive region of processed or preprocessed human myostatin RNA transcript, identified, in its processed form, by SEQ ID NO:6, and is capable of uptake by target muscle cells in the subject. In practicing the method, the compound is administered in an amount and at a dosage schedule t o produce an overall reduction in the level of serum Myostatin measured in the patient, and preferably to bring the myostatin level within the a range determined for normal, healthy individuals. |
